Landmark Hospital of Columbia

Landmark Hospital of Columbia is a 39-bed premier critical-care hospital located in Columbia, MO, less than two miles from the University of Missouri campus. Situated near two large acute care hospitals and the Truman VA hospital, it provides solutions for patients who require extended hospitalization for their medical care. The hospital provides its patients with exceptional medical care through innovative technologies and an experienced, caring medical team as patients’ journey toward healing.

As part of its commitment to patient safety, Landmark Columbia operates Synexis Air Purifier system, which uses hydrogen peroxide to reduce contaminants in the air. The system is proven to reduce the spread of COVID-19, MRSA, C. Diff, staph, e. coli, norovirus and influenza.

Our Specialties

  • Ventilator/tracheostomy weaning
  • Respiratory failure
  • Congestive heart failure
  • Severe stroke
  • Multi-system failure
  • Specialized wound care
  • Post-surgical/traumatic wounds
  • Diabetic ulcers and ischemic ulcers
  • Individualized in-house Tablo Dialysis services


  • CIHQ and COLA accredited

Brenda Hughes

CEO Landmark Hospital of Columbia

Brenda Hughes is a seasoned health care executive with more than 20 years’ experience in post-acute care. She has the ability to balance strategic decisions and financial discipline with a hands-on approach to leadership—resulting in strong employee, patient, and physician satisfaction. She is an engaging communicator and relationship builder with expertise in organizational planning, contract negotiations, team development, and increasing visibility for growth.

Landmark Hospital of Columbia Gallery